Open Access
Protein-protein interactions and gene expression regulation in HTLV-1 infected cells
Sebastien Legros1,Mathieu Boxus1,Jean Francois Dewulf1,Franck Dequiedt1,Richard Kettmann1,Jean Claude Twizere1
Cellular and Molecular Biology Unit, FUSAGx, 5030 Gembloux, Belgium
DOI: 10.2741/3518 Volume 14 Issue 11, pp.4138-4148
Published: 01 January 2009

Human T-cell leukemia virus type 1 (HTLV-1) propagates in CD4 or CD8 T cells and, after extended latency periods of 30-50 years, causes a rapidly fatal leukemia called adult T-cell leukemia/lymphoma (ATL). Infection with HTLV-1 is also associated with a degenerative neuromuscular disease referred to as tropical spastic paraparesis or HTLV-1-associated myelopathy. HTLV genome, in addition to the structural proteins and retroviral enzymes, codes for a region at its 3' end originally designated pX. The products of this region (Tax, Rex, p12I, p13II, p30II and HBZ) play important roles in deregulation of cellular functions by either directly disrupting cellular factors or altering transcription of viral and cellular genes. Here, we will review current knowledge of protein-protein interactions that regulate transcriptional functions of proteins encoded by the pX region.

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Sebastien Legros, Mathieu Boxus, Jean Francois Dewulf, Franck Dequiedt, Richard Kettmann, Jean Claude Twizere. Protein-protein interactions and gene expression regulation in HTLV-1 infected cells. Frontiers in Bioscience-Landmark. 2009. 14(11); 4138-4148.